Perlane, similar to Restylane, is a dermal filler injection and is a long-lasting gel that adds fullness and assists in reducing fine lines. Perlane is a synthetic gel form of hyaluronic acid and can be used to create a fullness on one’s lips as well as treat folds and facial wrinkles. Perlane is normally used to add more fullness to a person’s lips but can also be used on the body and other facial areas.